We study mechanisms of T-cell regulation suppressing the immune response against cancer, with the goal of devising new modalities to counteract these mechanisms for improving the activity of immunotherapy.
Specifically, our team is focused on determining the molecular cues controlling immunosuppressive T cells in cancer using various perturbations, including tumor metabolic alterations, immune checkpoint blockade, and epigenetic targeting.
We primarily investigate these mechanisms in solid tumors, where the immune system and the neoplastic disease are two distinct tissue entities and test these findings in the setting of B-cell lymphomas, where the malignant disease occurs in the immune system itself.
Work with us
We welcome a diverse set of talents and foster an interdisciplinary approach in the attempts to translate fundamental scientific discoveries into clinical innovations. We are always looking for talented and passionate students and post-docs to join our team and mission.
Get in touch if you wish to collaborate with us!